A mouse model of MSU-induced acute inflammation <i>in vivo</i> suggests imiquimod-dependent targeting of <i>Il-1β</i> as relevant therapy for gout patients
Alexandre Mariotte, Aurore de Cauwer, Chrystelle Po, Chérine Abou Fayçal, Angélique Pichot, Nicodème Paul, Ismael Aouadi, Raphaël Carapito, Benoı̂t Frisch, Cécile Macquin, Emmanuel Chatelus, Jean Sibilia, Jean‐Paul Armspach, Seiamak Bahram, Philippe Georgel
Abstract
: Our work reveals several key features of MSU-dependent inflammation and identifies novel therapeutic opportunities for gout patients.
Topics & Concepts
InflammationIn vivoImiquimodMedicinePolitical scienceImmunologyBiologyBiotechnologyGout, Hyperuricemia, Uric AcidVeterinary medicine and infectious diseasesInflammasome and immune disorders