Nickel-Catalyzed Enantioselective Coupling of Aldehydes and Electron-Deficient 1,3-Dienes Following an Inverse Regiochemical Course
Thomas Q. Davies, Jae Yeon Kim, Alois Fürstner
Abstract
C-substituted stereogenic centers. The use of a dienyl pinacolboronate instead of a sorbate ester is also possible, which opens access to valuable chiral borylated building blocks in optically active form.
Topics & Concepts
ChemistryStereocenterEnantioselective synthesisNickelCatalysisAlkenePhosphoramiditeLigand (biochemistry)Aldol reactionCombinatorial chemistryReductive eliminationStereochemistryOrganic chemistryReceptorBiochemistryOligonucleotideDNACatalytic C–H Functionalization MethodsOrganoboron and organosilicon chemistryAsymmetric Synthesis and Catalysis