Capturing the Conformational Ensemble of the Mixed Folded Polyglutamine Protein Ataxin-3
Alessandro Sicorello, Bartosz Różycki, Petr V. Konarev, Dmitri I. Svergun, Annalisa Pastore
Topics & Concepts
Polyglutamine tractSpinocerebellar ataxiaDeubiquitinating enzymeUbiquitinChemistryBiophysicsProtein structureC-terminusCell biologyComputational biologyCrystallographyBiochemistryBiologyAmino acidGeneHuntingtinMutantGenetic Neurodegenerative DiseasesMitochondrial Function and PathologyUbiquitin and proteasome pathways