Synthesis of Benzothiadiazine-1-oxides by Rhodium-Catalyzed C−H Amidation/Cyclization
Peng Shi, Yongliang Tu, Chenyang Wang, Deshen Kong, Ding Ma, Carsten Bolm
Abstract
A rhodium-catalyzed C−H amidation/cyclization sequence provides benzothiadiazine-1-oxides from sulfoximines and 1,4,2-dioxazol-5-ones in good yields. The reaction is characterized by a high functional group tolerance and, in contrast to most previous transformations of this type, is well-suited for S-alkyl-S-aryl-substituted sulfoximines.
Topics & Concepts
BenzothiadiazineChemistryRhodiumArylCatalysisAlkylSequence (biology)Medicinal chemistryFunctional groupCombinatorial chemistrySulfurOrganic chemistryPolymerBiochemistrySynthesis and Catalytic ReactionsCatalytic C–H Functionalization MethodsSulfur-Based Synthesis Techniques