Human pancreatic islet miRNA-mRNA networks of altered miRNAs due to glycemic status
Alexandros Karagiannopoulos, Jonathan L.S. Esguerra, Morten Gram Pedersen, Anna Wendt, Rashmi B. Prasad, Lena Eliasson
Abstract
-eQTLs and public GWAS data integration uncovered suggestive genomic signals of association with insulin secretion and T2D. The miRNA-driven network-based approach presented in this study contributes to a better understanding of impaired insulin secretion in T2D pathogenesis.
Topics & Concepts
microRNAIsletBiologyGeneGene expressionGlucose homeostasisRegulation of gene expressionPancreatic isletsGene silencingComputational biologyBioinformaticsGeneticsDiabetes mellitusEndocrinologyInsulin resistanceMicroRNA in disease regulationCancer-related molecular mechanisms researchPancreatic function and diabetes