An enzyme-mimicking reactive oxygen species scavenger targeting oxidative stress-inflammation cycle ameliorates IR-AKI by inhibiting pyruvate dehydrogenase kinase 4
Wenfang He, Chenguang Ding, Ting Lin, Binqi Wang, Wenjing Wang, Zhichao Deng, Tong Jin, Yiwei Shang, Danna Zheng, Ting Bai, Mingzhen Zhang, Runqing Li, Juan Jin, Qiang He
Abstract
: Collectively, CF@P, possessing antioxidant/anti-inflammatory properties by inhibiting PDK4, as well as imaging capabilities and superior biocompatibility, holds promise as a therapeutic strategy for IR-AKI.
Topics & Concepts
Oxidative stressReactive oxygen speciesInflammationChemistryLactate dehydrogenaseEnzymeOxidative phosphorylationPyruvate kinaseBiochemistryScavengerMedicineGlycolysisAntioxidantImmunologyBiochemical Acid Research StudiesATP Synthase and ATPases ResearchCancer, Hypoxia, and Metabolism