Effect of antibiotic pretreatment on bacterial engraftment after Fecal Microbiota Transplant (FMT) in IBS-D
Prashant Singh, Eric J. Alm, John M. Kelley, Vivian Cheng, Mark Smith, Zain Kassam, Judy Nee, Johanna Iturrino, Anthony Lembo
Abstract
= .002). The mean change in IBS-SSS and IBS-QOL from baseline were not significantly different among the four groups or between the three FMT groups combined vs. placebo at week 10. In summary, antibiotic pretreatment significantly reduced bacterial engraftment after FMT in patients with IBS-D.
Topics & Concepts
GastroenterologyMedicineInternal medicineRifaximinIrritable bowel syndromePlaceboClinical endpointDysbiosisAntibioticsMetronidazoleRandomized controlled trialBiologyPathologyDiseaseMicrobiologyAlternative medicineGastrointestinal motility and disordersClostridium difficile and Clostridium perfringens researchHelicobacter pylori-related gastroenterology studies