Enhanced viability and function of mesenchymal stromal cell spheroids is mediated <i>via</i> autophagy induction
Shobha Regmi, Pawan Kumar Raut, Shiva Pathak, Prakash Shrestha, Pil‐Hoon Park, Jee‐Heon Jeong
Abstract
: 3D-cultured MSCs; MSCs: mesenchymal stromal cells; NFE2L2/NRF2: nuclear factor, erythroid 2 like 2; PGE2: prostaglandin E2; PIK3C3/VPS34: phosphatidylinositol 3-kinase catalytic subunit type 3; PINK1: PTEN induced kinase 1; ROS: reactive oxygen species; siRNA: small interfering RNA; SIRT1: sirtuin 1; SOD2: superoxide dismutase 2; SQSTM1/p62: sequestosome 1; TGFB/TGF-β: transforming growth factor beta.
Topics & Concepts
AutophagyHMOX1Mesenchymal stem cellViability assayCell biologyBiologyDownregulation and upregulationCancer researchHIF1AHeme oxygenaseApoptosisAngiogenesisHemeBiochemistryEnzymeGeneMesenchymal stem cell researchAutophagy in Disease and TherapyHeme Oxygenase-1 and Carbon Monoxide