Anti-malarial humoral immunity: the long and short of it
Kai J. Rogers, Rahul Vijay, Noah S. Butler
Abstract
Humoral immunity is critical for limiting Plasmodium parasite infections and the severity of malaria. Naturally acquired immunity against malaria occurs inefficiently and protection is relatively short-lived. Here we review recent advances and explore emerging hypotheses regarding the molecular and cellular pathways that regulate Plasmodium parasite-specific B cell responses and durable anti-malarial humoral immunity.
Topics & Concepts
Humoral immunityBiologyImmunityMalariaImmunologyCellular immunityPlasmodium (life cycle)Immune systemPlasmodium falciparumLimitingParasite hostingVirologyEngineeringMechanical engineeringWorld Wide WebComputer scienceMalaria Research and ControlMosquito-borne diseases and controlComplement system in diseases