Prospect of Animal Models for Acute-on-chronic Liver Failure: A Mini-review
Hozeifa Mohamed Hassan, Jun Li
Abstract
Acute-on-chronic liver failure (ACLF) is a clinical syndrome that develops in patients with chronic liver diseases following a precipitating event and associated with a high mortality rate due to systemic multiorgan failure. Establishing a suitable and stable animal model to precisely elucidate the molecular basis of ACLF pathogenesis is essential for the development of effective early diagnostic and treatment strategies. In this context, this article provides a concise and inclusive review of breakthroughs in ACLF animal model development.
Topics & Concepts
MedicineIntensive care medicineContext (archaeology)Liver failureAnimal modelBioinformaticsInternal medicineBiologyPaleontologyLiver Disease and TransplantationLiver Disease Diagnosis and TreatmentDrug-Induced Hepatotoxicity and Protection