Bottom-up design of Ca2+ channels from defined selectivity filter geometry
Yulai Liu, Connor Weidle, Ljubica Mihaljević, Joseph L. Watson, Zhe Li, Luís Yu, Sagardip Majumder, Andrew J. Borst, Kenneth D. Carr, Ryan D. Kibler, Tamer M. Gamal El-Din, William A. Catterall, David Baker
Topics & Concepts
SelectivityIon channelTransmembrane proteinChemistryDivalentFilter (signal processing)Channel (broadcasting)Transmembrane domainBiological systemIonProtein designProtein structureHomogeneousKcsA potassium channelMaterials scienceStructural biologyCombinatorial chemistryMembraneAmino acid residueBiophysicsMolecular recognitionChemical physicsCryo-electron microscopyCrystallographyTopology (electrical circuits)NanotechnologyAmino acidComputer scienceProtein engineeringIon channel regulation and functionReceptor Mechanisms and SignalingNeuroscience and Neuropharmacology Research