USP14 negatively regulates RIG-I-mediated IL-6 and TNF-α production by inhibiting NF-κB activation
Hongrui Li, Jiazheng Quan, Xibao Zhao, Ling Jing, Weilin Chen
Topics & Concepts
Deubiquitinating enzymeRIG-IUbiquitinCell biologyGene knockdownBiologyInnate immune systemSignal transductionTumor necrosis factor alphaChemistryReceptorImmunologyGeneBiochemistryinterferon and immune responsesNF-κB Signaling PathwaysImmune Response and Inflammation