Structure of a 14-3-3ε:FOXO3a<sup>pS253</sup> Phosphopeptide Complex Reveals 14-3-3 Isoform-Specific Binding of Forkhead Box Class O Transcription Factor (FOXO) Phosphoproteins
S. Mathivanan, Puneeth Kumar Chunchagatta Lakshman, Manvi Singh, Saranya Giridharan, Keerthana Sathish, Manjunath A. Hurakadli, Kavitha Bharatham, Neelagandan Kamariah
Abstract
, providing a framework for the rational design of isoform-specific FOXO/14-3-3 protein-protein interaction inhibitors for therapy.
Topics & Concepts
PhosphopeptideIsothermal titration calorimetryChemistryProtein–protein interactionTranscription factorPhosphorylationGene isoformMolecular dynamicsBiophysicsCrystallographyBiochemistryBiologyComputational chemistryGene14-3-3 protein interactionsFOXO transcription factor regulationHeat shock proteins research