Organophotoredox-Catalyzed Direct C–H Amination of 2<i>H</i>-Indazoles with Amines
Sukanya Neogi, Asim Kumar Ghosh, Koushik Majhi, Sadhanendu Samanta, Golam Kibriya, Alakananda Hajra
Abstract
A general and practical method for the direct C–H amination of 2H-indazoles with a series of amines including aliphatic primary amines, secondary amines, azoles, and sulfoximines via organophotoredox-catalyzed oxidative coupling has been disclosed at room temperature under ambient air conditions. Additionally, this protocol is used for free aminated 2H-indazole synthesis. A mechanistic study revealed that a single electron transfer (SET) pathway might be involved in this reaction.
Topics & Concepts
ChemistryAminationCatalysisCombinatorial chemistryMedicinal chemistryStereochemistryOrganic chemistrySynthesis and Catalytic ReactionsCatalytic C–H Functionalization MethodsRadical Photochemical Reactions