Liposomes Loaded With Phosphatidylinositol 5-Phosphate Improve the Antimicrobial Response to Pseudomonas aeruginosa in Impaired Macrophages From Cystic Fibrosis Patients and Limit Airway Inflammatory Response
Noemi Poerio, Federica De Santis, Alice S. Rossi, Serena Ranucci, Ida De Fino, Sarah Ana Henriquez, Marco Maria D’Andrea, Fabiana Ciciriello, V. Lucidi, Roberto Nisini, Alessandra Bragonzi, Maurizio Fraziano
Abstract
. The treatment with ABL/PI5P significantly reduces pulmonary neutrophil infiltrate and the levels of KC and MCP-2 cytokines in the lungs, without affecting pulmonary bacterial load. Altogether, these results show that the ABL/PI5P treatment may represent a promising host-directed therapeutic approach to improve the impaired phagocytosis and to limit the potentially tissue-damaging inflammatory response in CF.
Topics & Concepts
Cystic fibrosisPseudomonas aeruginosaCystic fibrosis transmembrane conductance regulatorMicrobiologyPhagosomeBiologyImmunologyPhagocytosisChemistryBacteriaGeneticsCystic Fibrosis Research AdvancesVibrio bacteria research studiesBacterial biofilms and quorum sensing