Worldwide Exploration of Renal Replacement Outcomes Collaborative in Kidney Disease (WE-ROCK)
Shina Menon, Kelli A. Krallman, Ayse Akcan‐Arikan, Dana Y. Fuhrman, Stephen M. Gorga, Theresa Mottes, Nicholas J. Ollberding, Zaccaria Ricci, Natalja L. Stanski, David T. Selewski, Danielle E. Soranno, Michael Zappitelli, Huaiyu Zang, Katja M. Gist, Emily Ahern, Ayse Akcan‐Arikan, Issa Alhamoud, Rashid Alobaidi, Pilar Antón-Martín, Shanthi S. Balani, Matthew Barhight, Abby Basalely, Amee M. Bigelow, Gabriella Bottari, Andrea Cappoli, Eileen Ciccia, Michaela Collins, Denise Colosimo, Gérard Cortina, Mihaela Damian, Sara de la Mata Navazo, Gabrielle DeAbreu, Akash Deep, Kathy L Ding, Kristin Dolan, Sarah N. Fernández, Dana Y. Fuhrman, Ben Gelbart, Katja M. Gist, Stephen M. Gorga, Francesco Guzzi, Isabella Guzzo, Taiki Haga, Elizabeth Harvey, Denise C. Hasson, Taylor Hill-Horowitz, Haleigh Inthavong, Catherine Joseph, Ahmad Kaddourah, Aadil Kakajiwala, Aaron Kessel, S Korn, Kelli A. Krallman, David M. Kwiatkowski, Jasmine Lee, Laurance Lequier, Tina Madani Kia, Kenneth E. Mah, Eleonora Marinari, Susan D. Martin, Shina Menon, Tahagod Mohamed, Catherine Morgan, Theresa Mottes, Melissa Muff‐Luett, Siva P. Namachivayam, Tara M. Neumayr, Jennifer Nhan, Abigail Alexandra O'Rourke, Nicholas J. Ollberding, Matthew G. Pinto, Dua Qutob, Valeria Raggi, Stéphanie Reynaud, Zaccaria Ricci, Zachary A. Rumlow, María José Santiago, Emily See, David T. Selewski, Carmela Serpe, Alyssa Serratore, Ananya Shah, Weiwen V. Shih, Hyungoo Shin, Cara Slagle, Sonia Solomon, Danielle E. Soranno, Rachana Srivastava, Natalja L. Stanski, Michelle C. Starr, Erin K. Stenson, Amy E. Strong, Susan A. Taylor, Sameer Thadani, Amanda M. Uber, Brynna Van Wyk, Tennille N. Webb, Huaiyu Zang, Emily E. Zangla, Michael Zappitelli
Abstract
Introduction: Continuous renal replacement therapy (CRRT) is used for the symptomatic management of acute kidney injury (AKI) and fluid overload (FO). Contemporary reports on pediatric CRRT are small and single center in design. Large international studies evaluating CRRT practice and outcomes are lacking. Herein, we describe the design of a multinational collaborative. Methods: The Worldwide Exploration of Renal Replacement Outcomes Collaborative in Kidney Disease (WE-ROCK) is an international collaborative of pediatric specialists whose mission is to improve short- and long-term outcomes of children treated with CRRT. The aims of this multicenter retrospective study are to describe the epidemiology, liberation patterns, association of fluid balance and timing of CRRT initiation, and CRRT prescription with outcomes. Results: = 996, 0-25 years) admitted to an intensive care unit (ICU) and treated with CRRT for AKI or FO at 32 centers (in 7 countries) from 2018 to 2021. Demographics and clinical characteristics before CRRT initiation, during the first 7 days of both CRRT, and liberation were collected. Outcomes include the following: (i) major adverse kidney events at 90 days (mortality, dialysis dependence, and persistent kidney dysfunction), and (ii) functional outcomes (functional stats scale). Conclusion: The retrospective WE-ROCK study represents the largest international registry of children receiving CRRT for AKI or FO. It will serve as a broad and invaluable resource for the field of pediatric critical care nephrology that will improve our understanding of practice heterogeneity and the association of CRRT with clinical and patient-centered outcomes. This will generate preliminary data for future interventional trials in this area.