Enhanced oral absorption of insulin: hydrophobic ion pairing and a self-microemulsifying drug delivery system using a D-optimal mixture design
Yoon Tae Goo, Sangkil Lee, Ji Yeh Choi, Min Song Kim, Gi Hyeong Sin, Sun Ho Hong, Chang‐Hyun Kim, Seh Hyon Song, Young Wook Choi
Abstract
, 17.67%). The desirability function was 0.766, indicating excellent agreement between the predicted and experimental values. The stability of INS-SOS against gastrointestinal enzymes was noticeably improved in the SMEDDS, and the majority of INS remained in oil droplets during release. Following oral administration in diabetic rats, the optimized SMEDDS resulted in pharmacological availabilities of 3.23% (50 IU/kg) and 2.13% (100 IU/kg). Thus, the optimized SMEDDS is a good candidate for the practical development of oral delivery of peptide drugs such as INS.
Topics & Concepts
Drug deliveryDifferential scanning calorimetryMaterials scienceAbsorption (acoustics)ChromatographyChemistryNanotechnologyPhysicsComposite materialThermodynamicsDrug Solubulity and Delivery SystemsAdvanced Drug Delivery SystemsAnalytical Chemistry and Chromatography