Pentagalloylglucose disrupts the PALB2-BRCA2 interaction and potentiates tumor sensitivity to PARP inhibitor and radiotherapy
Jie Zeng, Jichang Han, Zhaorui Liu, Yu Meng, Hao Li, Jianzhong Yu
Topics & Concepts
Cancer researchPALB2PARP inhibitorRAD51DNA repairDNA damageHomologous recombinationPoly ADP ribose polymeraseNude mouseBiologyCancerChemistryMolecular biologyDNABiochemistryGeneticsMutationPolymeraseGermline mutationGeneDNA Repair MechanismsPARP inhibition in cancer therapyCell death mechanisms and regulation