Effective chimeric antigen receptor T cells against SARS-CoV-2
Xueyang Guo, Alexandra Kazanova, Stephanie Thurmond, H. Uri Saragovi, Christopher E. Rudd
Abstract
killing of S1-expressing cells by our SARS-CoV-2 CAR-Ts in mice. The successful generation of SARS-CoV-2 CAR-Ts represents a living vaccine approach for the treatment of COVID-19.
Topics & Concepts
PerforinChimeric antigen receptorGranzyme BAntigenCytolysisBiologyGranzymeVirologyCell biologyReceptorCytotoxic T cellChemistryMolecular biologyImmune systemIn vitroT cellImmunologyCD8BiochemistryCAR-T cell therapy researchSARS-CoV-2 and COVID-19 ResearchAdvancements in Semiconductor Devices and Circuit Design