Cyanine-Functionalized 2,2′-Bipyridine Compounds for Photocatalytic Cancer Therapy
Zilin Zhu, Li Wei, Ashish Kumar Yadav, Zhongxian Fan, Ashish Kumar, Mengzhao Miao, Samya Banerjee, Huaiyi Huang
Abstract
Recently, interest has been given to developing photocatalytic anticancer drugs. This area of research is dominated by metal complexes. Here, we report the potential of lysosome/mitochondria targeting cyanine appended bipyridine compounds as the organic photocatalytic anticancer agents. The organocatalyst (bpyPCN) not only exhibits light-induced NADH oxidation but also generates intracellular ROS to demonstrate anticancer activity. This is the first example of organic compound induced catalytic NADH photo-oxidation in an aqueous solution and in cancer cells.
Topics & Concepts
CyaninePhotocatalysisChemistryLysosomeAqueous solutionBipyridineCatalysisCombinatorial chemistryPhotochemistryBiochemistryOrganic chemistryEnzymeCrystal structureQuantum mechanicsPhysicsFluorescenceAdvanced Nanomaterials in CatalysisNanoplatforms for cancer theranosticsPorphyrin and Phthalocyanine Chemistry