Development of [1,2]oxazoloisoindoles tubulin polymerization inhibitors: Further chemical modifications and potential therapeutic effects against lymphomas
Marilia Barreca, Virginia Spanò, Roberta Rocca, Roberta Bivacqua, Anne‐Catherine Abel, Annalisa Maruca, Alessandra Montalbano, Maria Valeria Raimondi, Chiara Tarantelli, Eugenio Gaudio, Luciano Cascione, Andrea Rinaldi, Ruoli Bai, Michel O. Steinmetz, A.E. Prota, Stefano Alcaro, Ernest Hamel, Francesco Bertoni, Paola Barraja
Topics & Concepts
OxazoleMoietyColchicineChemistryLymphomaStereochemistryStructure–activity relationshipCancer researchTubulinRefractory (planetary science)PharmacologyComputational biologyMicrotubuleBiochemistryIn vitroMedicineBiologyImmunologyInternal medicineGeneticsAstrobiologySynthesis and Biological EvaluationSynthesis and Reactivity of HeterocyclesSynthesis and biological activity