Conjugated Dienones from Differently Substituted Cinnamaldehyde as Highly Potent Monoamine Oxidase-B Inhibitors: Synthesis, Biochemistry, and Computational Chemistry
Bijo Mathew, Jong‐Min Oh, Mohamed A. Abdelgawad, Ahmed Khames, Mohammed M. Ghoneim, Sunil Kumar, Lekshmi R. Nath, Sachithra Thazhathuveedu Sudevan, Della Grace Thomas Parambi, Clement Agoni, Mahmoud E. S. Soliman, Hoon Kim
Abstract
toward MAO-B and their possible binding mechanisms, showing high-affinity binding pocket interactions and conformation perturbations of the compounds with MAO-B, which were interpreted as the conformational dynamics of MAO-B. This study concluded that all the compounds tested were more potent MAO-B inhibitors than the reference drugs, and leading compounds could be further explored for their effectiveness in various kinds of neurodegenerative disorders.
Topics & Concepts
ChemistryIC50Monoamine oxidaseMonoamine oxidase BStereochemistryConjugated systemMonoamine oxidase ABiochemistryIn vitroEnzymeOrganic chemistryPolymerCholinesterase and Neurodegenerative DiseasesElectrochemical sensors and biosensorsParkinson's Disease Mechanisms and Treatments