Potential clinical use of azacitidine and MEK inhibitor combination therapy in PTPN11-mutated juvenile myelomonocytic leukemia
Santhosh Kumar Pasupuleti, Karen Chao, Baskar Ramdas, Rahul Kanumuri, Lakshmi Reddy Palam, Sheng Liu, Jun Wan, Colleen Annesley, Mignon L. Loh, Elliot Stieglitz, Michael J. Burke, Reuben Kapur
Topics & Concepts
Juvenile myelomonocytic leukemiaPTPN11TrametinibCancer researchMyeloproliferative neoplasmMEK inhibitorAzacitidineLeukemiaMAPK/ERK pathwayNeuroblastoma RAS viral oncogene homologBiologyInternal medicineMedicineKRASHaematopoiesisBone marrowStem cellMyelofibrosisCancerKinaseGeneGeneticsColorectal cancerDNA methylationGene expressionProtein Tyrosine PhosphatasesAcute Myeloid Leukemia ResearchChronic Lymphocytic Leukemia Research