Cooperatively enhanced photothermal-chemotherapy<i>via</i>simultaneously downregulating HSPs and promoting DNA alkylation in cancer cells
Yang Zou, Daipeng Huang, Shan He, Xuefang Song, Weijian Liu, Wen Sun, Jianjun Du, Jiangli Fan, Xiaojun Peng
Abstract
enhanced the DNA alkylation of chemotherapy drugs. Surprisingly, we first found that the therapeutic efficacy of PTT was improved owing to the down-regulation of heat shock protein 70 (HSP70) by chemotherapy. The two treatments had a synergistic promotion effect achieving higher cancer cell killing efficiency. Under 808 nm light irradiation, Cy-S-S-Cbl could effectively realize selective killing of cancer cells and tumor growth inhibition. Therefore, we strongly believe that this efficient cooperative design strategy will provide a new idea to improve the treatment efficiency of prodrugs.
Topics & Concepts
Photothermal therapyAlkylationDNACancerCancer researchCancer cellChemotherapyChemistryDNA damageCell biologyBiophysicsNanotechnologyMaterials scienceBiochemistryBiologyGeneticsCatalysisNanoplatforms for cancer theranosticsRNA Interference and Gene DeliveryExtracellular vesicles in disease