Exposure to fluoride exacerbates the cognitive deficit of diabetic patients living in areas with endemic fluorosis, as well as of rats with type 2 diabetes induced by streptozotocin via a mechanism that may involve excessive activation of the poly(ADP ribose) polymerase-1/P53 pathway
Jie Xiang, Xiaolan Qi, Kun Cao, Long‐Yan Ran, Xiaoxiao Zeng, Xiao Xiao, Wei Liao, Wen-Wen He, Wei Hong, Yan He, Zhi‐Zhong Guan
Topics & Concepts
StreptozotocinMechanism (biology)Diabetes mellitusFluorideCognitionMedicineCognitive deficitInternal medicineEndocrinologyCognitive impairmentPsychiatryChemistryPhysicsInorganic chemistryQuantum mechanicsFluoride Effects and RemovalBone and Dental Protein StudiesFolate and B Vitamins Research