Ferroptosis in osteosarcoma: A promising future
Xiang Liu, Shaowen Du, Shengdong Wang, Kaishan Ye
Abstract
The incidence of osteosarcoma (OS) is increasing year by year, and the prognosis of patients with advanced OS is extremely poor due to the tendency of recurrence and chemotherapy resistance after surgery. Ferroptosis is a novel form of programmed cell death (PCD) that kills cells through iron-dependent lipid peroxidation. Current studies have shown that ferroptosis is closely related to OS and could reduce chemotherapy resistance to a certain extent, which has great therapeutic potential. In this paper, we review the regulatory mechanism of ferroptosis and its research progress in OS, hoping to provide new help for the clinical treatment of OS.
Topics & Concepts
OsteosarcomaLipid peroxidationChemotherapyCancer researchMedicineProgrammed cell deathIncidence (geometry)Mechanism (biology)ApoptosisOncologyBioinformaticsInternal medicineBiologyOxidative stressBiochemistryEpistemologyPhilosophyPhysicsOpticsFerroptosis and cancer prognosisCancer, Lipids, and MetabolismRNA modifications and cancer