Metal-free reductive coupling of aliphatic aldehydes/ketones with 4-cyanopyridines: expanded scope and mechanistic studies
Liuzhou Gao, Guoqiang Wang, Hui Chen, Jia Cao, Xiaoshi Su, Xueting Liu, Mo Yang, Xu Cheng, Shuhua Li
Abstract
A practical B<sub>2</sub>pin<sub>2</sub> mediated reductive coupling of 4-cyanopyridine with aliphatic aldehydes/ketones has been established. This metal-free protocol provides a convenient route to construct a wide range of C<sub>4</sub>-pyridine-functionalized alcohols.
Topics & Concepts
ChemistryPyridineCoupling (piping)Scope (computer science)MetalCombinatorial chemistryOrganic chemistryMetallurgyComputer scienceProgramming languageMaterials scienceCatalytic C–H Functionalization MethodsCatalytic Cross-Coupling ReactionsRadical Photochemical Reactions