The CD22-IGF2R interaction is a therapeutic target for microglial lysosome dysfunction in Niemann-Pick type C
John V. Pluvinage, Jerry Sun, Christel Claes, Ryan A. Flynn, Michael S. Haney, Tal Iram, Xiang-Ling Meng, Rachel Chanel Lindemann, Nicholas M. Riley, Emma Danhash, Jean Paul Chadarevian, Emma Tapp, David Gate, Sravani Kondapavulur, Inma Cobos, Sundari Chetty, Anca M. Pașca, Sergiu P. Pașca, Elizabeth Berry‐Kravis, Carolyn R. Bertozzi, Mathew Blurton‐Jones, Tony Wyss‐Coray
Abstract
mutant induced pluripotent stem cell–derived microglia-like cells without harming oligodendrocytes in vitro. These findings reinforce the differences between mouse and human microglia and provide a candidate microglia-directed immunotherapeutic to treat NPC.
Topics & Concepts
LysosomeMedicineNeuroscienceChemistryBiologyBiochemistryEnzymeLysosomal Storage Disorders ResearchAutoimmune and Inflammatory Disorders ResearchCytomegalovirus and herpesvirus research