Towards safer anti-inflammatory therapy: synthesis of new thymol–pyrazole hybrids as dual COX-2/5-LOX inhibitors
Mostafa M. M. El-Miligy, Ahmed K. Al-Kubeisi, Mohamed G. Bekhit, Saad R. El‐Zemity, Rasha A. Nassra, A. A. B. HAZZAA
Abstract
superior gastrointestinal safety profile (no ulceration) as celecoxib.
Topics & Concepts
CelecoxibIn vivoPharmacologyChemistryIn vitroPyrazoleThymolDiclofenac SodiumMedicineBiochemistryStereochemistryBiologyEssential oilBiotechnologyChromatographyInflammatory mediators and NSAID effectsSynthesis of β-Lactam CompoundsSynthesis and Biological Evaluation