Phosphoglycerate Mutase 5 Knockdown Alleviates Neuronal Injury After Traumatic Brain Injury Through Drp1-Mediated Mitochondrial Dysfunction
Yuhua Chen, Kai Gong, Quanhua Xu, Jiao Meng, Tianlin Long, Cuicui Chang, Zhanxiang Wang, Wei Liu
Abstract
Drp1 activation (dephosphorylation of p-Drp1 on Ser622 and phosphorylation of Drp1 on Ser643)-mediated mitochondrial dysfunction. The data may open a window for developing new drugs to prevent the neuropathology of TBI.
Topics & Concepts
MitophagyMitochondrionNeuroprotectionCell biologyPhosphoglycerate mutaseMFN2Gene knockdownProgrammed cell deathBiologyPharmacologyAutophagyBiochemistryGlycolysisApoptosisMitochondrial DNAmitochondrial fusionMetabolismGeneMitochondrial Function and PathologyATP Synthase and ATPases ResearchMetabolism and Genetic Disorders