Breaking barriers for glioblastoma with a path to enhanced drug delivery
Imran Noorani, Jorge de la Rosa
Abstract
Progress in treatment for glioblastoma is hindered by the blood-brain barrier (BBB). In genetic mouse models recapitulating brain invasion and abnormal angiogenesis of human glioblastoma, Cai and colleagues demonstrate that optical modulation of the BBB with nanoparticles boosts intratumoural chemotherapy concentration, prolonging survival. We discuss prospects for clinical translation of exemplary innovative techniques.
Topics & Concepts
GlioblastomaAngiogenesisBlood–brain barrierDrug deliveryCancer researchTranslation (biology)ChemotherapyMedicineGliomaComputational biologyBiologyNanotechnologyCentral nervous systemInternal medicineMaterials scienceGeneMessenger RNABiochemistryGlioma Diagnosis and TreatmentNanoplatforms for cancer theranosticsAdvanced Electron Microscopy Techniques and Applications