Circulating microRNAs and Clinicopathological Findings of Papillary Thyroid Cancer: A Systematic Review
Georgios Geropoulos, Kyriakos Psarras, Maria Papaioannou, Dimitrios Giannis, Maria Meitanidou, Konstantinos Kapriniotis, Nikolaos Symeonidis, T. Pavlidis, T. Pavlidis, Konstantinos Sapalidis, Nada Ahmed, Tarek Abdel‐Aziz, Mohammad Eddama
Abstract
BACKGROUND/AIM: Papillary thyroid cancer (PTC) is the most common endocrine malignancy with a rising incidence. There is a need for a non-invasive preoperative test to enable better patient counselling. The aim of this systematic review was to investigate the potential role of circulating microRNAs (miRNAs) in the diagnosis and prognosis of PTC. MATERIALS AND METHODS: A systematic literature search was performed using MEDLINE, Cochrane, and Scopus databases (last search date was December 1, 2021). Studies investigating the expression of miRNAs in the serum or plasma of patients with PTC were deemed eligible for inclusion. RESULTS: I avid metastases (13 miRNAs), and tumor recurrence (2 miRNAs) was also depicted in this study. CONCLUSION: MiRNAs provide a potentially promising role in the diagnosis and prognosis of PTC. There is a correlation between miRNA expression profiles and specific clinicopathological features of PTC. However, to enable their use in clinical practice, further clinical studies are required to validate the predictive value and utility of miRNAs as biomarkers.