Docosahexanoic acid signals through the Nrf2–Nqo1 pathway to maintain redox balance and promote neurite outgrowth
Jennifer Drolet, Brodie Buchner-Duby, Morgan G. Stykel, Carla Coackley, Jing X. Kang, David W.L., Scott D. Ryan
Abstract
blocks the effects of DHA on the axodendritic compartment. Collectively, these data support a role for the Nrf2-NQO1 pathway in DHA-mediated axodendritic development and protection from agrochemical exposure.
Topics & Concepts
BiologyNeuriteRedoxCell biologyAntioxidantBalance (ability)BiochemistryNeuroscienceIn vitroChemistryOrganic chemistryGenomics, phytochemicals, and oxidative stressTryptophan and brain disordersAdipose Tissue and Metabolism