Recent insights into zebrafish cardiac regeneration
Andrés Sanz-Morejón, Nadia Mercader
Abstract
In humans, myocardial infarction results in ventricular remodeling, progressing ultimately to cardiac failure, one of the leading causes of death worldwide. In contrast to the adult mammalian heart, the zebrafish model organism has a remarkable regenerative capacity, offering the possibility to research the bases of natural regeneration. Here, we summarize recent insights into the cellular and molecular mechanisms that govern cardiac regeneration in the zebrafish.
Topics & Concepts
ZebrafishBiologyRegeneration (biology)Model organismMyocardial infarctionHeart failureCell biologyNeuroscienceInternal medicineGeneticsMedicineGeneCongenital heart defects researchMultilevel Inverters and ConvertersCongenital Heart Disease Studies