Tetrahydrocurcumin protects against sepsis-induced acute kidney injury via the SIRT1 pathway
Lu Li, Xiaoxi Liu, Shasha Li, Qingyan Wang, Hongru Wang, Menglu Xu, Yanxin An
Abstract
Ac-p65: acetylated p65; Ac-foxo 1: acetylated forkhead box O1; AKI: acute kidney injury; BUN: blood urea nitrogen; CAT: catalase; DHE: dihydroethidium; GPx: glutathione peroxidase; GSH: reduced glutathione; IL-1β: Interleukin-1 beta; IL-6: Interleukin-6; KIM-1: kidney injury molecule 1; MDA: malondialdehyde; SCr: serum creatinine; SIRT1: silent information regulator 1; SOD: superoxide dismutase; THC: tetrahydrocurcumin; TNF-α: tumor necrosis factor-alpha; TUNEL: TdT-mediated dUTP Nick-End Labeling; UAlb/Cr: urine micro albumin/creatinine.
Topics & Concepts
SepsisOxidative stressMedicineAcute kidney injuryKidneyInflammationPharmacologyRenal functionTUNEL assayApoptosisInternal medicineBiochemistryChemistryImmunohistochemistryHeme Oxygenase-1 and Carbon MonoxideAcute Kidney Injury ResearchThermal Regulation in Medicine