Ultrasound-mediated piezoelectric nanoparticle modulation of intrinsic cardiac autonomic nervous system for rate control in atrial fibrillation
Jiapeng Han, Yuanzheng Zhang, Xiaofei Wang, Guocheng Zhang, Zhiyao Yu, Changyi Wang, Tianyou Xu, Zhen Zhou, Xiaomeng Yang, Xiaoxing Jin, Chenzhe Liu, Liping Zhou, Yueyi Wang, Baopeng Tang, Shishang Guo, Hong Jiang, Lilei Yu
Abstract
piezoelectric nanoparticle group had reduced ventricular rates in the sinus rhythm and atrial fibrillation models after stimulating the IRGP by applying ultrasound. In addition, transient stimulation by BTNPs did not lead to sustained neuronal excitation in the IRGP. The activation of the BTNPs did not induce inflammation or thermal damage effects in the IRGP. Ultrasound-mediated BTNP neuromodulation can significantly reduce the ventricular rate by stimulating the IRGP. Thus, ultrasound-mediated BTNP neuromodulation is a potential therapy for atrial fibrillation rate control.