Palladium Catalyzed Aminocarbonylation of Benzylic Ammonium Triflates with Nitroarenes: Synthesis of Phenylacetamides
Li‐Miao Yang, Shanshan Li, You‐Ya Zhang, Jin‐Liang Lu, Jing‐Tong Deng, Ai‐Jun Ma, Xiang‐Zhi Zhang, Shu‐Yu Zhang, Jin‐Bao Peng
Abstract
Abstract A palladium catalyzed reductive aminocarbonylation of benzylic ammonium triflates with nitroarenes for the synthesis of phenylacetamides was developed. Using Pd(acac) 2 /DPPF catalyst system, a range of different substituted phenylacetamides were prepared in moderate to good yields from benzylic ammonium triflates and nitroarenes through Csp 3 −N bond cleavage. A variety of alkyl, aryl, and halide substituents on both substrates can be used, and many useful functional groups can be tolerated. magnified image
Topics & Concepts
ChemistryCatalysisHalideArylPalladiumAmmoniumAlkylCleavage (geology)Organic chemistryMedicinal chemistryCombinatorial chemistryGeotechnical engineeringFracture (geology)EngineeringChemical Synthesis and AnalysisCatalytic C–H Functionalization MethodsSynthesis and Catalytic Reactions