[Au<sup>III</sup>(N^N)Br<sub>2</sub>](PF<sub>6</sub>): A Class of Antibacterial and Antibiofilm Complexes (N^N = 2,2′-Bipyridine and 1,10-Phenanthroline Derivatives)
M. Carla Aragoni, Enrico Podda, Veronica Caria, Silvia A. Carta, M. Francesca Cherchi, Vito Lippolis, Simone Murgia, Germano Orrù, Gabriele Pippia, Alessandra Scano, Alexandra M. Z. Slawin, J. Derek Woollins, Anna Pintus, Massimiliano Arca
Abstract
High Resolution Image Download MS PowerPoint Slide A series of new complexes of general formula [Au III (N^N)Br 2 ](PF 6 ) (N^N = 2,2′-bipyridine and 1,10-phenanthroline derivatives) were prepared and characterized by spectroscopic, electrochemical, and diffractometric techniques and tested against Gram-positive and Gram-negative bacterial strains ( Staphylococcus aureus, Streptococcus intermedius, Pseudomonas aeruginosa, and Escherichia coli ), showing promising antibacterial and antibiofilm properties.
Topics & Concepts
ChemistryStaphylococcus aureusPhenanthrolineEscherichia coliAntibacterial activityPseudomonas aeruginosaElectrochemistryBipyridineStereochemistryMedicinal chemistryBacteriaCrystallographyCrystal structureBiochemistryBiologyPhysical chemistryGeneElectrodeGeneticsMetal complexes synthesis and propertiesMetal-Organic Frameworks: Synthesis and ApplicationsFluorine in Organic Chemistry