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Design, synthesis and antimicrobial activity of novel quinoline-2-one hybrids as promising DNA gyrase and topoisomerase IV inhibitors

Mohammed A. I. Elbastawesy, Fatma A. Mohamed, Islam Zaki, Mohammed Issa Alahmdi, Seham Alzahrani, Hayat Ali Alzahrani, Hesham A. M. Gomaa, Bahaa G. M. Youssif

2023Journal of Molecular Structure19 citationsDOI

Topics & Concepts

DNA gyraseChemistryNovobiocinTopoisomeraseQuinolineAntimicrobialTopoisomerase IVCiprofloxacinMinimum inhibitory concentrationStereochemistryBacillus subtilisProton NMRQuinoloneCarbon-13 NMRDNAEscherichia coliCombinatorial chemistryBiochemistryBacteriaOrganic chemistryAntibioticsGeneGeneticsBiologyCancer therapeutics and mechanismsSynthesis and biological activitySynthesis and Biological Evaluation
Design, synthesis and antimicrobial activity of novel quinoline-2-one hybrids as promising DNA gyrase and topoisomerase IV inhibitors | Litcius