Breviscapine targets EGFR and SRC to abrogate diabetes-driven GPX4 lactylation and ferroptosis resistance in gastric cancer
Hong Mei Hu, Jennifer Deng, Yan Pan, Zi Han Wang, Jing Zhang, Xiaoping Gu, Song Fan, Ji Zhong Zhao
Topics & Concepts
Cancer researchGPX4CancerCancer cellChemistryDownregulation and upregulationProgrammed cell deathMechanism of actionApoptosisIn vitroProto-oncogene tyrosine-protein kinase SrcWarburg effectMechanism (biology)Bystander effectMediatorPharmacologyCell biologyLipid peroxidationSuppressorCytoprotectionBiologyHEK 293 cellsFerroptosis and cancer prognosisRNA modifications and cancerDrug Transport and Resistance Mechanisms