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Activation of anti-oxidant Keap1/Nrf2 pathway modulates efficacy of dihydroartemisinin-based monotherapy and combinatory therapy with ionizing radiation

Sina Bader, Julia Wilmers, Martin Pelzer, Verena Jendrossek, Justine Rudner

2021Free Radical Biology and Medicine34 citationsDOI

Topics & Concepts

Clonogenic assayKEAP1Cancer researchGlutathioneOxidative stressReactive oxygen speciesDihydroartemisininProgrammed cell deathCancer cellChemistryPharmacologyCell biologyCancerBiologyApoptosisBiochemistryImmunologyArtemisininEnzymeTranscription factorGeneMalariaPlasmodium falciparumGeneticsDrug Transport and Resistance MechanismsGenomics, phytochemicals, and oxidative stressParasites and Host Interactions
Activation of anti-oxidant Keap1/Nrf2 pathway modulates efficacy of dihydroartemisinin-based monotherapy and combinatory therapy with ionizing radiation | Litcius