Sulfatase-cleavable linkers for antibody-drug conjugates
Jonathan D. Bargh, Stephen J. Walsh, Albert Isidro‐Llobet, Soleilmane Omarjee, Jason S. Carroll, David R. Spring
Abstract
against HER2-positive cells, while maintaining selectivity over HER2-negative cells. We propose that the stability, solubility and synthetic tractability of our arylsulfate linkers make them an attractive new motif for cleavable ADC linkers, with clear benefits over the widely used dipeptidic linkers.
Topics & Concepts
ConjugateSulfataseDrugChemistryAntibodyCombinatorial chemistryProdrugBiochemistryPharmacologyEnzymeBiologyImmunologyMathematicsMathematical analysisMonoclonal and Polyclonal Antibodies ResearchHER2/EGFR in Cancer ResearchGlycosylation and Glycoproteins Research