Comparing the greenness and sustainability of three routes to an HIV protease inhibitor intermediate
Stephanie Gina Akakios, Moira L. Bode, Roger A. Sheldon
Abstract
The greenness and sustainability of three different routes for the synthesis of an advanced intermediate for a group of HIV protease inhibitors used in antiretroviral (ARV) therapy are compared.
Topics & Concepts
ProteaseHIV-1 proteaseHuman immunodeficiency virus (HIV)SustainabilityProtease inhibitor (pharmacology)Antiretroviral therapyChemistryVirologyPharmacologyMedicineEnzymeViral loadBiochemistryBiologyEcologyChemistry and Chemical Engineering