An overview of mammalian p38 mitogen-activated protein kinases, central regulators of cell stress and receptor signaling
Jiahuai Han, Jianfeng Wu, John Silke
Abstract
The p38 family is a highly evolutionarily conserved group of mitogen-activated protein kinases (MAPKs) that is involved in and helps co-ordinate cellular responses to nearly all stressful stimuli. This review provides a succinct summary of multiple aspects of the biology, role, and substrates of the mammalian family of p38 kinases. Since p38 activity is implicated in inflammatory and other diseases, we also discuss the clinical implications and pharmaceutical approaches to inhibit p38.
Topics & Concepts
p38 mitogen-activated protein kinasesKinaseMitogen-activated protein kinaseOpen peer reviewCell biologyBiologyPlant biologySignal transductionProtein kinase AReceptorProtein-Serine-Threonine KinasesGeneticsBotanyMelanoma and MAPK PathwaysCell death mechanisms and regulationCancer Mechanisms and Therapy