Mast cells as important regulators in the development of psoriasis
Xuyue Zhou, Kun Chen, Jia-An Zhang
Abstract
Psoriasis is a chronic inflammatory immune skin disease mediated by genetic and environmental factors. As a bridge between innate and adaptive immunity, mast cells are involved in the initiation, development, and maintenance of psoriasis by interactions and communication with a variety of cells. The current review describes interactions of mast cells with T cells, Tregs, keratinocytes, adipocytes, and sensory neurons in psoriasis to emphasize the important role of mast cell-centered cell networks in psoriasis.
Topics & Concepts
PsoriasisImmune systemMast cellImmunologyAcquired immune systemMast (botany)Innate immune systemDiseaseBiologyImmunityInflammationMedicineCell biologyPathologyMast cells and histamineUrticaria and Related ConditionsPsoriasis: Treatment and Pathogenesis