Gold nanoclusters elicit homeostatic perturbations in glioblastoma cells and adaptive changes of lysosomes
Dušica Maysinger, Evan Rizzel Gran, Franck Bertorelle, Hussein Fakhouri, Rodolphe Antoine, Esha Kaul, Dana M. Samhadaneh, Ursula Stochaj
Abstract
: Taken together, this study explores the subcellular and molecular effects induced by gold nanoclusters and shows their effectiveness to regulate lysosome biology. Our results indicate that gold nanoclusters cause homeostatic perturbations without marked cell loss. Notably, cells adapt to the challenge inflicted by gold nanoclusters. These new insights provide a framework for the further development of gold nanocluster-based applications in biological sciences.
Topics & Concepts
NanoclustersGlioblastomaHomeostasisCell biologyChemistryCancer researchNeuroscienceBiologyNanotechnologyMaterials scienceNanocluster Synthesis and ApplicationsGold and Silver Nanoparticles Synthesis and ApplicationsAlzheimer's disease research and treatments