Inhibition of two-pore channels in antigen-presenting cells promotes the expansion of TNFR2-expressing CD4 <sup>+</sup> Foxp3 <sup>+</sup> regulatory T cells
Tianzhen He, De Yang, Xiao-Qing Li, Mengmeng Jiang, Md Sahidul Islam, Shaokui Chen, Yibo Chen, Yang Yang, Chon‐Kit Chou, Anna Trivett, Joost J. Oppenheim, Xin Chen
Abstract
Inhibition of TPCs up-regulates tmTNF expression on APCs by disrupting mTACE expression and promotes expansion of TNFR2 + Tregs.
Topics & Concepts
AntigenMolecular biologyFOXP3Cell biologyChemistryBiologyPhysicsGeneticsImmune systemCalcium signaling and nucleotide metabolismIon Channels and ReceptorsAdenosine and Purinergic Signaling