Distinct designer diamines promote mitophagy, and thereby enhance healthspan in <i>C. elegans</i> and protect human cells against oxidative damage
Vijigisha Srivastava, Veronica Zelmanovich, Virendra Shukla, R. Patrick Abergel, Irit Cohen, Shmuel A. Ben‐Sasson, Einav Gross
Abstract
. Moreover, it enhances mitophagy and protects against oxidative injury in rodent and human cells. Initial structural characterization suggests simple rules for the design of compounds with improved bioactivity, opening the way for a new generation of agents with a potential to promote healthy aging.
Topics & Concepts
MitophagyOxidative stressAutophagyBiologyMitochondrionCell biologyOxidative phosphorylationPopulationBiochemistryApoptosisMedicineEnvironmental healthGenetics, Aging, and Longevity in Model OrganismsAutophagy in Disease and TherapyCircadian rhythm and melatonin