Lac-Phe (N-lactoyl-phenylalanine)
Shuke Xiao, Veronica L. Li, Jonathan Z. Long
Abstract
Lac-Phe (N-lactoyl-phenylalanine) is a conjugate of lactate and phenylalanine and the most abundant member of the N-lactoyl-amino acids. Lac-Phe is formed by CNDP2-mediated condensation of lactate and phenylalanine. Plasma Lac-Phe levels are elevated by diverse stimuli that increase circulating lactate or phenylalanine levels, or increase glycolytic flux, in both mice and humans. These stimuli include sprint exercise, metformin treatment, feeding, phenylketonuria, and mitochondrial disease.
Topics & Concepts
PhenylalanineMetaboliteInternal medicineEndocrinologyGlycolysisAdenylate kinaseBiologyBiochemistryGluconeogenesisAmino acidChemistryMetabolismEnzymeMedicineAdipose Tissue and MetabolismMuscle metabolism and nutritionMetabolomics and Mass Spectrometry Studies