Characteristics of subjective cognitive decline associated with amyloid positivity
Olin Janssen, Willemijn J. Jansen, Stephanie J. B. Vos, Merçé Boada, Lucilla Parnetti, Tomasz Gabryelewicz, Tormod Fladby, José Luís Molinuevo, Sylvia Villeneuve, Jakub Hort, Stéphane Epelbaum, Alberto Lleó, Sebastiaan Engelborghs, Wiesje M. van der Flier, Susan Landau, Julius Popp, Anders Wallin, Philip Scheltens, Marcel G. M. Olde Rikkert, Peter J. Snyder, Chris Rowe, Gaël Chételat, Agustı́n Ruiz, Marta Marquié, Elena Chipi, Steffen Wolfsgruber, Michael T. Heneka, Henning Boecker, Oliver Peters, Jonas Alexander Jarholm, Lorena Rami, Adrià Tort‐Merino, Alexa Pichet Binette, Judes Poirier, Pedro Rosa‐Neto, Jiří Cerman, Bruno Dubois, Marc Teichmann, Daniel Alcolea, Juan Fortea, María Belén Sánchez‐Saudinós, Jarith L. Ebenau, Cornelia Pocnet, Marie Eckerström, Louisa I. Thompson, Victor L. Villemagne, Rachel F. Buckley, Samantha C. Burnham, Marion Delarue, Yvonne Freund‐Levi, Åsa K. Wallin, Inez H.G.B. Ramakers, Magda Tsolaki, Hilkka Soininen, Harald Hampel, Luiza Spiru, for the Alzheimer's Disease Neuroimaging Initiative, FACEHBI study group, Betty M. Tijms, Rik Ossenkoppele, Frans R.J. Verhey, Frank Jessen, Pieter Jelle Visser
Abstract
INTRODUCTION: The evidence for characteristics of persons with subjective cognitive decline (SCD) associated with amyloid positivity is limited. METHODS: In 1640 persons with SCD from 20 Amyloid Biomarker Study cohort, we investigated the associations of SCD-specific characteristics (informant confirmation, domain-specific complaints, concerns, feelings of worse performance) demographics, setting, apolipoprotein E gene (APOE) ε4 carriership, and neuropsychiatric symptoms with amyloid positivity. RESULTS: Between cohorts, amyloid positivity in 70-year-olds varied from 10% to 76%. Only older age, clinical setting, and APOE ε4 carriership showed univariate associations with increased amyloid positivity. After adjusting for these, lower education was also associated with increased amyloid positivity. Only within a research setting, informant-confirmed complaints, memory complaints, attention/concentration complaints, and no depressive symptoms were associated with increased amyloid positivity. Feelings of worse performance were associated with less amyloid positivity at younger ages and more at older ages. DISCUSSION: Next to age, setting, and APOE ε4 carriership, SCD-specific characteristics may facilitate the identification of amyloid-positive individuals.